Led by science, not hype

  • Rigorous R&D platform

    End-to-end product development run by our in-house team of scientists.

  • Scientifically validated claims

    Quantified by our proprietary MolClock and Skin Age Modeling methods.

  • Ongoing clinical studies

    Conducted by independent, third-party research organizations.

  • Peer-reviewed publications

    The gold standard for scientific research and in skin care.

      OUR BREAKTHROUGH PEPTIDE

      OS-01: the new standard in peptide technology

      Think of OS-01 as a reset button for your skin, helping clear away the senescent cells thatcause wrinkles, hyperpigmentation, and crepiness. As the first peptide scientificallyproven to reduce cellular senescence in the skin, 0S-01 does what other peptides can't.01

      6 visible signs of senescence

      • Lines and wrinkles

        Caused by a decline in collagen and elastin production.

      • Loss of elasticity

        Decreased elastin also contributes to lack of firmness.

      • Uneven skin tone

        Irregular melanin production leads to hyperpigmentation.

      • Rough texture

        Compromised skin cell renewal leaves a dry, uneven surface.

      • Loss of volume

        Linked to a decrease in hyaluronic acid, collagen, and elastin.

      • Thinning skin

        Slower cell turnover contributes to a weakened skin barrier.

        The brains behind the breakthrough

        About

        Scientifically proven,visible results.

        A daily skin longevity treatment scientifically proven totarget the root cause of skin aging so body's skin feelshealthier and looks younger.

        800+Peptides Screened

        We screened over 800 peptides to develop 0S-01: The firstpeptide proven to reverse skin's biological age oi by reducingsenescent cell accumulation. o2

        7+Years of Research

        Our approach is research-first, leveraging evidence-baseddata to navigate the complexities of human biology.

        17+Patents and Publications

        Our proprietary technology, including our rigorous in-houseR&D process and the 0S-01 peptide, is supported by three

        Tremella Fuciformis Sporocarp MushroomExtract

        Up to 400x times more moisturizing than normal hyaluronicacid, this mushroom extract works with glycerin and beet-derived betaine to greatly enhance skin softness andmoisture.

        Sulforaphane

        A potent antioxidant phytonutrient with antimicrobial andanti-infiammatory properties.

        Saccharide lsomerate

        A prebiotic shown to support the healthy bacteria on skin.

        See your skin transform

        Instantly

        Hydrated and soothed skin.

        Within 2 weeks

        Sustained hydration and smoothness,with improved skin barrier.

        3 Within 8 weeks

        Stronger, more resilient skin with reducedsagging and flakiness.

        Frequently Asked Questions

        What are peptides?

        Peptides are short chains of amino acids. They represent a broad class of molecules with many jobs, from forming the building blocks of larger proteins to acting as cellular messengers. Peptides found naturally in the body (called endogenous peptides), play a crucial role in tissue growth, hormone regulation, and other biological processes. Exogenous peptides, which can be injected, ingested or delivered topically like OS-01, can send out signals to skin cells to trigger collagen and hyaluronic acid production, aid in cellular repair, and help strengthen the skin barrier.01,02,03

        How does OS-01 work?

        OS-01 reduces the accumulation of senescent cells. These cells release inflammatory chemicals that cause neighboring cells to become dysfunctional, kicking off a domino effect in skin and accelerating skin aging. By reducing this inflammatory response, OS-01 helps prevent the accumulation of senescent cells in skin, improving key skin aging biomarkers and keeping other skin cells healthy and thriving.01,02,03

        Who is OneSkin for?

        OneSkin is for everyone. Whether you’re taking a preventative approach or want your skin’s health and appearance to reflect how you feel on the inside, our scientifically proven products work at the cellular level to keep your skin looking, feeling, and acting younger and healthier as you age.01,02,03

        What skin concerns does OneSkin address?

        Through lab studies and clinical studies, our products have been shown to combat the visible and invisible signs of aging, from collagen loss and thinning skin to a compromised barrier function.01,02,03

        To learn more about the specific benefits of each product, visit oneskin.co/claims.

        How long does it take to see results?

        With daily use, you can expect to see visible results within 12 weeks, though some people see changes even sooner. This time frame allows OS-01 to work at the cellular level, improving the long-term health and appearance of your skin.01,02,04

        01 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

        02 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242

        03 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

        04 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042